Glycopeptides containing O-linked glycans can be synthesized quickly with good purity using microwave-enhanced SPPS. Preparation of a peptide substrate of WbwA (a sialic acid glycosyltransferase), was completed in 3 h 10 min with 68% purity on the Liberty Blue automated microwave peptide synthesizer. Synthesis of an analog of APF (antiproliferative factor) conjugated to the TUS nuclear localization sequence was achieved in 1 h 8 min with 73% purity using the Liberty PRIME automated microwave peptide synthesizer.

Fully automated synthesis of head-to-tail cyclized peptides can be performed rapidly and with excellent purity using the Liberty Blue and Liberty PRIME peptide synthesizers. Microwave SPPS benefits not only the linear assembly but also the subsequent cyclization step with exceptional purity achieved on a variety of difficult biologically important peptides. The one-pot Fmoc SPPS cycles used on the Liberty PRIME provide even further benefit for synthesis time and waste reduction.

Der Liberty PRIME Peptid-Synthesizer synthetisiert sehr effizient schwierige Konotoxine einschließlich einer neuartigen Sequenz (SxIIIC) von Conus striolatus, die eine einzigartige Eigenschaft zur Behandlung von neurologischen Erkrankungen hat.